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ea0090ep41 | Adrenal and Cardiovascular Endocrinology | ECE2023

The role of CRH test in predicting the efficacy of unilateral adrenalectomy in Bilateral Macronodular Adrenal Hyperplasia

Tizianel Irene , Detomas Mario , Deutschbein Timo , Carla Scaroni , Ceccato Filippo

Background and Aim: Bilateral Macronodular Adrenal Hyperplasia (BMAH) is a rare form of adrenal Cushings syndrome (CS). The treatment of choice in patients with BMAH and overt CS is bilateral adrenalectomy (B-Adx), which however implies lifelong glucocorticoid and mineralocorticoid replacement therapy. Unilateral adrenalectomy (U-Adx) has been proposed as an alternative to B-Adx, especially in case of clearly asymmetric adrenal size. Our aim was to determine predictive f...

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ea0081p533 | Adrenal and Cardiovascular Endocrinology | ECE2022

Renin indicates the mineralocorticoid activity of fludrocortisone: a 6-year study in primary adrenal insufficiency

Ceccato Filippo , Torchio Marianna , Tizianel Irene , Barbot Mattia , Sabbadin Chiara , Betterle Corrado , Scaroni Carla

Context: Fludrocortisone (FC) is the mineralocorticoid (MC) replacement treatment for patients with primary adrenal insufficiency (PAI). Objective: To explore the dose of FC treatment and its relationship with glucocorticoid therapy, sodium, potassium, renin and clinical parameters. Design: Longitudinal study.Setting: Monocentric cohort.Patients: Data of 193 patients with PAI (130 autoi...

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ea0090p416 | Pituitary and Neuroendocrinology | ECE2023

Treatment, complications and mortality of Cushing’s Disease: twenty-year report from a referral Centre

Mondin Alessandro , Ceccato Filippo , Voltan Giacomo , Mazzeo Pierluigi , Tizianel Irene , Scaroni Carla , Barbot Mattia

Context: Cushings disease (CD) is rare condition burdened by several systemic complications that in turn increase mortality. The main goal of CD treatment is to promptly reduce cortisol excess, but whether remission can revert cortisol-related complications and guarantee a normal life expectancy remains debated. Aim: To assess the prevalence of cortisol-related complications and mortality in a large monocentric cohort of CD patients followed at our...

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ea0099ep196 | Adrenal and Cardiovascular Endocrinology | ECE2024

Metabolic impact of dual-release hydrocortisone in patients with congenital adrenal syndrome: a retrospective study

Mazzeo Pierluigi , Ceccato Filippo , Voltan Giacomo , Tizianel Irene , Mondin Alessandro , Lazzara Martina , Bavaresco Alessandro , Barbot Mattia

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder characterized by impaired cortisol secretion and androgen excess. The mainstay of CAH treatment is glucocorticoid (GC) replacement, necessary to avoid adrenal crisis and manage androgen excess. The delicate balance between GC under/overtreatment is crucial to prevent metabolic and cardiovascular complications. Dual-release hydrocortisone (Plenadren®) is once-daily modified-release formulat...

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ea0099ep1229 | Late Breaking | ECE2024

Steroidogenesis inhibitors in mild/subclinical cushing’s syndrome: results from a retrospective cohort of patients

Bavaresco Alessandro , Ceccato Filippo , Mazzeo Pierluigi , Lazzara Martina , Voltan Giacomo , Tizianel Irene , Mondin Alessandro , Barbot Mattia

Cushings syndrome (CS) is a severe disease associated with elevated morbidity and mortality rates, up to four times higher than those of general population. Whether the positive effects of cortisol-lowering medications is widely documented in overt CS cases, its impact on mild or subclinical CS remains unclear since limited clinical investigations have been performed in patients with subclinical hypercortisolism. In this study, we retrospectively analysed clinical data f...